Download PDF by Sun Hongmao: A practical guide to rational drug design

By Sun Hongmao

ISBN-10: 0081001053

ISBN-13: 9780081001059

This publication will not be an exhaustive survey overlaying all features of rational drug layout. as an alternative, it will offer serious information via real-world examples. appropriate case reports can be offered and analyzed to demonstrate the subsequent: tips to optimize a lead compound no matter if one has excessive or low degrees of structural details; tips on how to derive hits from opponents' energetic compounds or from  Read more...

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By Sun Hongmao

ISBN-10: 0081001053

ISBN-13: 9780081001059

This publication will not be an exhaustive survey overlaying all features of rational drug layout. as an alternative, it will offer serious information via real-world examples. appropriate case reports can be offered and analyzed to demonstrate the subsequent: tips to optimize a lead compound no matter if one has excessive or low degrees of structural details; tips on how to derive hits from opponents' energetic compounds or from  Read more...

Show description

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Kruse, A. ; Chung, K. ; Kobilka, T. ; Thian, F. ; Chae, P. ; Mathiesen, J. ; Shah, S. ; Lyons, J. ; Gellman, S. ; Weis, W. ; Sunahara, R. ; Kobilka, B. K. Nature 2011, 477, 549. 9. ; Dore, A. ; Tehan, B. ; Mason, J. ; Marshall, F. H. Br J Pharmacol 2014, 171, 3132–3145. 10. ; Wang, M. ; Marshall, F. ; Stevens, R. C. Trends Pharmacol Sci 2014, 35, 12. 11. Rasmussen, S. ; Choi, H. ; Rosenbaum, D. ; Kobilka, T. ; Thian, F. ; Edwards, P. ; Ratnala, V. ; Fischetti, R. ; Schertler, G. ; Weis, W. ; Kobilka, B.

29. Murray, C. ; Hartshorn, M. ; Wallis, N. J Med Chem 2007, 50, 1116. 30. ; de Groot, B. L. PLoS Comput Biol 2010, 6, e1000634. 31. ; Ota, M. Nucleic Acids Res 2012, 40, D554. 14 A Practical Guide to Rational Drug Design 32. ; Luk, K. ; Zhang, X. Bioorg Med Chem Lett 2013, 23, 6610. 33. Hopkins, A. ; Keseru, G. ; Leeson, P. ; Rees, D. ; Reynolds, C. H. Nat Rev Drug Discov 2014, 13, 105. 34. ; Ghosh, G. Mol Cell 2004, 15, 661. 35. ; Nukina, N. Mol Cell Biol 2008, 28, 3663. 36. De Bondt, H. ; Jones, H.

McGovern, S. ; Shoichet, B. K. J Med Chem 2003, 46, 2895. 27. Erickson, J. ; Robertson, D. ; Lewis, R. ; Vieth, M. J Med Chem 2004, 47, 45. 28. ; Li, M. ; Sussman, J. L. Acta Crystallogr D Biol Crystallogr 2012, 68, 13. 29. Murray, C. ; Hartshorn, M. ; Wallis, N. J Med Chem 2007, 50, 1116. 30. ; de Groot, B. L. PLoS Comput Biol 2010, 6, e1000634. 31. ; Ota, M. Nucleic Acids Res 2012, 40, D554. 14 A Practical Guide to Rational Drug Design 32. ; Luk, K. ; Zhang, X. Bioorg Med Chem Lett 2013, 23, 6610.

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A practical guide to rational drug design by Sun Hongmao


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