By N. M. Hooper
A panel of hugely expert investigators describe intimately their cutting-edge biochemical, phone organic, and molecular organic ideas for learning the molecular foundation of Alzheimer's illness. those conveniently reproducible, step by step tools specialize in paintings with the amyloid precursor protein and the amyloidogenic peptide A?, but in addition include-with the hot identity of presenilin proteins-techniques for picking out the constitution and organic functionality of those proteins. additionally, there are chapters overlaying the tau protein and its position in Alzheimer's sickness, in addition to an introductory dialogue of the background of the affliction, its genetic foundation, and the presently to be had and attainable destiny healing brokers. state of the art and huge ranging, Alzheimer's disorder: equipment and Protocols presents prepared entry to confirmed, reproducible equipment for elucidating the molecular foundation of this most typical senile dementia.
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Additional resources for Alzheimer's Disease: Methods and Protocols (Methods in Molecular Medicine)
Roch, J. , Sundsmo, M. , Otero, D. , and Saitoh, T,(1993) Amino acid sequence R E M S represents the active domain of amyloid PIA4 protein J. 121,879-886. precursor that promotes fibroblast growth. D. , and 82. , Roch, J. , Otero, Saitoh, T. J. Neurosci. 14,5461-5470. 83. , Roch, J. , Jin, L. W. and Saitoh, T. (1994) Secreted form of amyloid P/A4 protein precursor (APP) binds to two distinct APP binding sites on rat B103 neuron-like cells through two different domains, but only one site is involved in neuritotropic activity.
And 82. , Roch, J. , Otero, Saitoh, T. J. Neurosci. 14,5461-5470. 83. , Roch, J. , Jin, L. W. and Saitoh, T. (1994) Secreted form of amyloid P/A4 protein precursor (APP) binds to two distinct APP binding sites on rat B103 neuron-like cells through two different domains, but only one site is involved in neuritotropic activity. J. Neurochem. 63,495-500. 84. Goodman,Y. and Mattson, M. P. (1994) Secreted forms of P-amyloid precursor protein protect hippocampal neurons against amyloid P-peptide-induced oxidative injury.
Neuron 8, 159-168. 20. Goedert, M. (1996) Tau protein and the neurofibrillary pathology of Alzheimer’s disease. Ann. NYAcad. Sci. 777, 121-131 21. , Trojanowski, J. , et al. (1994) Biopsy-derived adult human brain tau is phosphorylated at many of the same sites asAlzheimer’s disease paired helical filament tau. Neuron 13,989-1002. 22. Consensus report of the Working Group on: “Molecular and Biochemical Markers of Alzheimer’s Disease” (1998) Neurobiol. Aging 19. 23. , Lemaire, H. , Salbaum, J. , Masters, C.
Alzheimer's Disease: Methods and Protocols (Methods in Molecular Medicine) by N. M. Hooper